Use Cases

Discover how research teams and biopharma organisations use ImmuneWatch DETECT for antigen-specific T cell monitoring across oncology, transplantation, and infectious disease. From TIL product characterisation to immune monitoring in clinical trials, these real-world applications show how TCR repertoire analysis becomes clinically actionable data. Explore our use cases, white papers, and interactive demos and see how epitope-specific TCR annotation is accelerating the development of cell therapies, cancer vaccines, and diagnostics.

March 5, 2026

Characterising TIL Products with ImmuneWatch DETECT: From Black Box to TCR-specificity Annotated Therapy

Learn how ImmuneWatch DETECT characterises TIL therapy products — identifying tumor-reactive clones, confirming antigen specificity, and screening for viral bystanders.

December 5, 2025

Cracking the Code of Cold Tumors: 4 Key Takeaways from CuraCell’s Approach to TIL Therapy

How does CuraCell tackle TIL therapy in cold solid tumors? 4 key lessons on TCR sequencing, bystander T cell screening, and antigen-specific T cell identification for cell therapy developers.

October 28, 2025

Beyond the Sequence: How Obsidian Therapeutics Overcame 4 Hurdles in Implementing TCR Repertoire Sequencing

Arman Aksoy of Obsidian Therapeutics shares 4 hurdles in implementing TCR repertoire sequencing for cell therapy — from feasibility to TCR epitope annotation with ImmuneWatch DETECT.

September 25, 2025

ImmuneWatch DETECT reveals a potential viral trigger for lung transplant failure

Researchers from the University of Pittsburgh have applied ImmuneWatch DETECT to gain new insights into the causes of chronic lung allograft dysfunction (CLAD), a major complication following lung transplantation

September 24, 2025

Contextualising T-cell receptor repertoires from chronic lymphocytic leukemia patients with ImmuneWatch DETECT

Researchers from DKFZ in Heidelberg and their collaborators have identified a promising new target for immunotherapy in chronic lymphocytic leukemia (CLL).

September 18, 2025

Using ImmuneWatch DETECT within Platforma to annnotate epitope and HLA specificity of TCRs

This webinar dives into the latest discoveries linking Epstein-Barr Virus (EBV) to Primary Sclerosing Cholangitis (PSC) and demonstrates how large-scale immune profiling technologies, including TCR sequencing (TCR-seq), reveal critical insights into adaptive immune responses.

September 10, 2025

What Are Your T Cells Really Doing? A Journey Through TCR Single-Cell Data and Epitope Annotation

In this post, we will guide you through a comprehensive analysis journey, from UMAP clustering to clonotype tracking and epitope annotation, revealing how T cells behave, interact, and respond to their environment.

December 6, 2024

Predicting epitope specificity for an entire T cell atlas

In this study, researchers used ImmuneWatch DETECT to explore the antigen-specificity of a several TCR cluster that had been generated using 149 single-cell samples.

Read the manuscript

August 22, 2024

ImmuneWatch DETECT Assists in Uncovering the Role of CMV in T-Cell Leukemia

Recently, our DETECT tool played a role in research conducted by Dr. Utpal Davé, Associate Professor at Indiana University School of Medicine, aimed at understanding T-cell large granular lymphocytic leukemia (T-LGL).

Watch the Video

July 31, 2024

T-Cell Monitoring in Cancer Vaccine Research

This poster showcased how ImmuneWatch DETECT is used for T-cell monitoring in cancer vaccine research, featuring a case study of a stage IV colorectal cancer patient.

Download the Poster

January 11, 2024

New white paper on TCR sequencing for cancer vaccine developers

To know the efficacy of your cancer vaccine, it is crucial to analyse the T cell response. Because of its versatility, TCR sequencing is a rising tool to monitor such immune responses. However, the full potential of TCR sequencing remains unrealised at present.

Download the Whitepaper

April 21, 2023

Release of our Reverse Vaccinology white paper

Are you looking to implement AI in your vaccine development process? Meet reverse vaccinology: An AI-driven procedure that allows vaccinologists to determine potential vaccine targets in a faster, cheaper, and more sustainable fashion.

Download the Whitepaper

December 16, 2021

ImmuneWatch releases white paper evaluating the effect of mutations gathered in the SARS-COV-2 Omicron variant on T cell immunity

Omicron, the latest SARS-COV-2 variant of concern is characterized by a large number of mutations. In our first white paper, we evaluate the effect of these mutations on T-cell immunity by applying a T-cell receptor (TCR)/epitope interaction model.

Download the Whitepaper